![]() ![]() Thus, by curtailing virus replication and enhancing expression of MHC class II antigens, LV-IFN may contribute to the induction and augmentation of the host's lymphoproliferative response to the virus. Clearance of caprine arthritis encephalitis virus infection by host immune responses (eg, sterilizing immunity) does not generally occur because of stable integration of provirus into the host genome and latent persistence in long-lived cells throughout the body. Third, it induces expression of class II (Ia) antigens of the major histocompatibility complex on cells of macrophage lineage. In Fenner's Veterinary Virology (Fifth Edition), 2017. The virus is able to infect goats and occasionally sheep and other related ruminants 2. Second, it restricts the rate of virus replication in mature macrophages by preventing virus maturation. Caprine arthritis-encephalitis virus (CAEV) is one of the small ruminant lentiviruses (SRLV), viruses that belong to the genus Lentivirus of the family Retrovirdae 1. Early phylogenetic studies suggested that SRLV can be divided into five genetic groups, A to E. Firstly, it retards the rate of maturation of monocytes and thus indirectly slows the rate of virus replication. Caprine Arthritis Encephalitis (CAE) disease is a world-wide goat infectious disease 1,2,3,4,5,6,7 caused by Small Ruminant Lentiviruses (SRLV). LV-IFN is a non-glycosylated protein of 54,000 to 64,000 daltons and has biological properties which have several implications for pathogenesis. Interest in this disease has increased in recent years mainly for two reasons. Co-cultivation of sheep or goat lymphocytes with macrophages infected with visna or CAE viruses results in production of a unique interferon (LV-IFN). Caprine arthritis-encephalitis (CAE) is a disease in goats which occurs worldwide 3. Virus replication in the monocyte-macrophage results in lesions characterized by mononuclear cell infiltration of the central nervous system (CNS), lungs, synovium and mammary gland and their draining lymph nodes. ![]() The virus life cycle is closely associated with maturational factors in the cells monocytes support the early stages of the replication cycle which goes to completion only when the cells mature to macrophages. The prototype lentiviruses, visna/maedi of sheep and arthritis-encephalitis virus of goats (CAEV), infect cells of the monocyte-macrophage system and replicate at a restricted level in these cells. 1981 178:713–719.Lentiviruses are unique retroviruses which cause diseases with long incubation periods and prolonged clinical courses. Caprine arthritis-encephalitis: Clinical features and presence of antibody in selected goat populations. The small ruminant lentiviruses include the prototype for the genus, visna-maedi virus (VMV) as well as caprine arthritis encephalitis virus (CAEV). Biological characterization of the virus causing leukoencephalitis and arthritis in goats. Narayan O., Clements J.E., Strandberg J.D., Cork L.C., Griffin D.E. Chronic arthritis in goats caused by a retrovirus. Maedi-visna: The meningoencephalitis in naturally occurring cases. 3087.īenavides J., Garcia-Pariente C., Fuertes M., Ferreras M.C., Garcia-Marin J.F., Juste R.A., Perez V. ![]() Lippincott Williams & Wilkins Philadelphia, PA, USA: 2001. At present, the clinical consequence of CAEV-associated renal injury is not clear.ĬAEV SRLV TFBS goat interstitial nephritis kidney lentivirus promoter.įields B.N., Knipe D.M., Howley P.M., Griffin D.E. Despite the TFBS conservation, the isolates demonstrated a degree of phylogenetic diversity. Within the viral promoter (U3) region, known transcription factor binding sites (TFBSs) were generally conserved, although one viral isolate had a duplication of the U3 A region encoding a second gamma-activated site (GAS). Cardiac lesions (vascular, myocardial or endocardial) were also identified in four of six animals. These goats had microscopic evidence of inflammatory renal injury (interstitial nephritis) with detectable renal immunolabeling for CAEV antigen in three of six animals and amplifiable proviral sequences consistent with CAEV in all six animals. One of the animals had CAEV antigen-associated thrombotic arteritis resulting in infarction of both the kidney and heart. Here we describe six goats with chronic, multisystemic CAEV infections in conjunction with CAEV-associated renal lesions. Clinically affected animals generally manifest with one or more of these classic CAEV-associated tissue lesions however, CAEV-associated renal inflammation in goats has not been reported in the peer-reviewed literature. Caprine arthritis encephalitis virus (CAEV) is a monocyte/macrophage-tropic lentivirus that primarily infects goats resulting in a well-recognized set of chronic inflammatory syndromes focused on the joint synovium, tissues of the central nervous system, pulmonary interstitium and mammary gland. ![]()
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![]() ![]() All the while they are ganging up on you, your party and Incarnate will be tearing them to pieces without concern for their own defense. ![]() Enemies won’t be able to resist attacking you because you will have the Glass Cannon Talent, meaning you can be CCed through Armour. The way this Build works is that you’ll Summon your Incarnate before or at the beginning of combat, and then buff it and cast Deflective Barrier and ideally Heart of Steel. This Build makes use of Poison to heal yourself, as well replenish Armour via the Living Armour Talent. The Undeath Incarnate Build is an Undead Tank/Summoner hybrid Build that actually induces enemies to attack you, while using Skill that replenish Armour to keep you alive, allowing your Incarnate to attack while you soak up damage and punish enemies for targeting you. Divinity Original Sin 2 Builds: Undeath Incarnate (Tank/Summoner) There are many Builds you can make in Divinity: Original Sin 2, and in this Build Guide we’re going to be taking a look at the Undeath Incarnate. Pillars of Eternity 2 Guides Pillars of Eternity 2 GuidesĪs promised here is the next Divinity: Original Sin 2 Enhanced Edition Build Guide, which is an Undead Summoner/Tank Build that can withstand all kinds of punishment while your other party members are free to spend their Action Points attacking without fear of retribution.Party Combinations Guide: Magic, Physical and Mixed.Divinity Original Sin 2 Guides Divinity Original Sin 2 Guides.Pathfinder Wrath of the Righteous Guides Pathfinder Wrath of the Righteous Guides.Baldur’s Gate 3 Guides Baldur’s Gate 3 Guides. ![]()
![]() ![]() Queen themselves had their share of songs that uncannily resembled other songs:.It didn't work, and he was ultimately forced to give songwriting credits and royalties to both artists. Vanilla Ice tried to avoid paying royalties for "Ice Ice Baby"'s musical background by adding an extra note to "Under Pressure" by Queen and David Bowie.Daughtry's "Waiting For Superman" has a riff that sounds almost the same as Far East Movement's "Rockateer". ![]() Bree Sharp's "America" sounds VERY similar to The La's' "There She Goes" (as made famous by Sixpence None the Richer)."Baby Come and Get It" by The Pointer Sisters contains a riff very similar to The Rolling Stones "Can't Get No Satisfaction".The lead synth melody is also similar to Proto Man's theme from Mega Man 3. The chorus of "Oh Yes You're There, Everyday" is suspiciously similar to the Dungeon Theme from The Legend of Zelda(though that itself was inspired by Deep Purple's "April")." Lune de fiel " is noted to be similar to Tony Montana's theme from Scarface (1983).Even more noticeable: compare "Midnight City" to The Chainsmokers' " Paris ", as well as Mike Posner's " Looks Like Sex ". Midnight City was released in 2011, while Sleepwalking was released in 2013. Some people will note similarities in the overall structures of "Midnight City" and The Chain Gang of 1974's "Sleepwalking".And the chorus lyrics on "Angel" are clearly inspired by "Angel of the Morning" by Merrilee Rush. Miller is credited as a composer on "Angel". Shaggy's "Angel" also sounds suspiciously similar to Steve Miller Band "The Joker.Beyoncé "Hold Up" sounds like Shaggy's "Angel". ![]() B.E.R's "Night Begins to Shine" opening theme is similar to Blondie's "Call Me" However "Night Begins to Shine" was created to be an 80's tribute.Murray Gold's "Love Don't Roam", made for the 2006 Doctor Who Christmas Special " The Runaway Bride" sounds a lot like "The Snake" by Al Wilson.This verse was also sung in the movie "La Bamba", plus they each have guitar solos after. Verse 3 of Elvis Presley's "I need your love tonight" sounds similiar to Los Lobos'/Ritchie Valens' "Come On Let's Go".On the flip side, Nick Jonas’ “Introducing Me” (from the Camp Rock 2 soundtrack) sounds like a faster, sillier version of “I’m Yours”. ![]()
![]() ![]() In shopping cart please choose "Lithuania" in address section and DPD & Omniva parcel terminal lists will open automatically. After dispatching it takes 2 days to reach Lithuania (might be 1 day to reach Vilnius, Kaunas and Klaipeda). Its a faster delivery method and fee for DPD service is 4,95 EUR and for Omniva 6,66 EUR (tax included).
![]() Stick one in the glove compartment, replace it or check that it’s still good every two or three years. Third: Keep a fob battery in the carĪny large grocery store or pharmacy will sell the batteries that go in key fobs. Yes, this is homework, but doing your homework is better on your couch than in a cold parking lot at 2 a.m. The lock is often hidden behind a faceplate to keep the door handle pretty. This also means learning where the mechanical lock is on your door and how to access it. Learn what the key fob can do and learn how to get the physical key out of the fob. You can roll all the windows up and down on a 2012 Honda Accord while outside the car if you learn the proper buttons and key placement, same goes for a 2018 Honda Pilot. Example: You can start a 2021 Chevy Tahoe with a key fob that doesn’t contain a battery by putting the fob in the driver’s side cupholder. Second: Know your key fobĪutomakers pack a ton of features into key fobs, including some that might not be explained in the owner’s manual. The 2000 Ford F-150, for example, responds to a combination of pressing the driver’s power door lock button in between powering the truck on and off, or using the panic button on the fob and turning the ignition on three times to reset the system. The Internet can be so much faster than roadside assistance. Unless you’re driving a one-of-one hypercar, someone has encountered the situation you’re in and either discussed it in a forum or uploaded a video of it to YouTube. There are hundreds of millions of cars on the road in the U.S. Our first three tips fall under the heading, “An ounce of prevention is worth a pound of cure.” First: Google it If your car won’t start and you suspect it’s the car’s immobilizer, here are some tips for getting the show back on the road. Or an actual theft attempt might have activated the immobilizer, so you’ll need to do the auto equivalent of dual-factor authorization and a Captcha to prove you’re not a thief nor a ![]() Or the anti-theft transponders in the car might communicate properly with the one in the key. If theĬar battery’s been replaced, sometimes the system forgets its connection to the car key. How to get around your car's anti-theft device Here are several tricks to let your car know you're a friend, not foeĪnti-theft electronics can go on the fritz for a number of innocent reasons. ![]() ![]() ![]() The response is unsettling: the king is to expect not a human son-in-law, but rather a dragon-like creature who harasses the world with fire and iron and is feared by even Jupiter and the inhabitants of the underworld. Her father suspects that they have incurred the wrath of the gods, and consults the oracle of Apollo. Consequently, he falls deeply in love with Psyche and disobeys his mother's order.Īlthough her two humanly beautiful sisters have married, the idolized Psyche has yet to find love. He instead scratches himself with his own dart, which makes any living thing fall in love with the first thing it sees. Cupid is sent to shoot Psyche with an arrow so that she may fall in love with something hideous. Venus is offended, and commissions Cupid to work her revenge. It was rumored that she was the second coming of Venus, or the daughter of Venus from an unseemly union between the goddess and a mortal. The youngest and most beautiful was Psyche, whose admirers, neglecting the proper worship of Aphrodite (love goddess Venus), instead prayed and made offerings to her. There were once a king and queen, rulers of an unnamed city, who had three daughters of conspicuous beauty. Story Psyche's Wedding ( Pre-Raphaelite, 1895) by Edward Burne-Jones Īlthough the tale resists explication as a strict allegory of a particular Platonic argument, Apuleius drew generally on imagery such as the laborious ascent of the winged soul ( Phaedrus 248) and the union with the divine achieved by Soul through the agency of the daimon Love ( Symposium 212b). ![]() The happy ending for Psyche is supposed to assuage Charite's fear of rape, in one of several instances of Apuleius's irony. It occurs within a complex narrative frame, with Lucius recounting the tale as it in turn was told by an old woman to Charite, a bride kidnapped by pirates on her wedding day and held captive in a cave. Īs a structural mirror of the overarching plot, the tale is an example of mise en abyme. Psyche's story has some similarities, including the theme of dangerous curiosity, punishments and tests, and redemption through divine favor. Transformed into a donkey by magic gone wrong, Lucius undergoes various trials and adventures, and finally regains human form by eating roses sacred to Isis. The novel itself is a first-person narrative by the protagonist Lucius. The tale of Cupid and Psyche (or "Eros and Psyche") is placed at the midpoint of Apuleius's novel, and occupies about a fifth of its total length. In Apuleius Psyche Honoured by the People (1692–1702) from a series of 12 scenes from the story by Luca Giordano ![]() Though Psyche is usually referred to in Roman mythology by her Greek name, her Roman name through direct translation is Anima. The story has been retold in poetry, drama, and opera, and depicted widely in painting, sculpture, and even wallpaper. Ever since, the reception of Cupid and Psyche in the classical tradition has been extensive. 1370, but the editio princeps dates to 1469. The story of Cupid and Psyche was known to Boccaccio in c. The story's Neoplatonic elements and allusions to mystery religions accommodate multiple interpretations, and it has been analyzed as an allegory and in light of folktale, Märchen or fairy tale, and myth. Although the only extended narrative from antiquity is that of Apuleius from 2nd century AD, Eros and Psyche appear in Greek art as early as the 4th century BC. The tale concerns the overcoming of obstacles to the love between Psyche ( / ˈ s aɪ k iː/ Greek: Ψυχή, Greek pronunciation:, "Soul" or "Breath of Life") and Cupid (Latin Cupido, "Desire") or Amor ("Love", Greek Eros, Ἔρως), and their ultimate union in a sacred marriage. Cupid and Psyche is a story originally from Metamorphoses (also called The Golden Ass), written in the 2nd century AD by Lucius Apuleius Madaurensis (or Platonicus). ![]() ![]() ![]() N protein contains three dynamic disordered regions that house putative transiently-helical binding motifs. Here we combine single-molecule spectroscopy with all-atom simulations to uncover the molecular details that contribute to N protein function. “ Protein structure (full)” By Thomas Shafee – Own Work ( CC BY 4.The SARS-CoV-2 nucleocapsid (N) protein is an abundant RNA-binding protein critical for viral genome packaging, yet the molecular details that underlie this process are poorly understood.“ Tetrapeptide structural formulae v.1” By Ju – Own work (Public Domain) via Commons Wikimedia.“ Biomolecules:Protein 1.” Protein Sequences (Primary Structure),.The main difference between N terminus and C terminus is the position of the peptide. In peptide naming, the C terminus contains the final amino acid of the peptide. Therefore, it contains a free carboxylic group at the final amino acid. However, the C terminus ends the peptide where the ribosome stops the synthesis of amino acids. On the other hand, in the peptide naming, the N terminus contains the first amino acid. Generally, it contains a free amine group in the first amino acid of the peptide. N terminus is the starting end of the peptide where the ribosome starts the synthesis of amino acids. In brief, N terminus and C terminus are the two ends of a peptide. The N terminus of a protein contains signal peptides that target a protein to a secretory pathway while the C terminus of the protein contains retention signals for protein sorting. The ribosome starts the translation of messenger RNA to produce the N terminus of the peptide while the ribosome ends the translation of messenger RNA to produce C terminus. Moreover, N terminus is the start of the peptide while C terminus is the end of the peptide. N terminus contains a free amine group while C terminus contains a free carboxyl group. N terminus is the amino terminus of the peptide while C terminus is the carboxylic terminus of the peptide. N terminus refers to the front end of a polypeptide chain, which has a free (unattached) amine (NH2) group, while the C terminus refers to the end of a polypeptide chain that consists of an amino acid with a free carboxyl group. Both ends are important in protein sequencing.ĭifference Between N-terminus and C-terminus Definition.Peptides are named from the N-terminal end to the C-terminal end.N-terminus and C-terminus are two ends of the peptide molecule.Similarities Between N-terminus and C-terminus Hence, the carboxylic end of the amino acid is always free in the growing protein chain. The bond that forms between the two amino acids is the peptide bond. Therefore, the incoming amino acid links to the peptide chain from the amine group. In general, amino acids link to the amino acid sequence from the N terminus to the C terminus. A protein is made up of an amino acid sequence. It also contains a free carboxylic group. What is C-terminusĬ terminus is the final end of the peptide. ![]() One of the methods of protein sequencing is N terminal sequencing, which is also known as gas phase sequencing, Edman sequencing, or Edman degradation. In addition, protein sequencing determines the sequence of the amino acids in a protein. Since it is the starting end of the protein, the naming of the amino acids of the polypeptide chain also starts from the N terminus. In the amino acid sequence, methionine contains a free amine group.įurthermore, the N terminus contains the first amino acid of the amino acid sequence of a protein. Therefore, it contains the first amino acid of the protein, which is methionine. The N terminus is the starting end of the above-mentioned amino acid sequence. A protein is made up of a sequence of amino acids. Generally, an amino acid is the building block of the protein or a peptide chain. N terminus is the starting end of the peptide. – Comparison of Key Differences Key TermsĬ-terminus, N-terminus What is N-terminus Difference Between N-terminus and C-terminus Similarities Between N-terminus and C-terminusĤ. Peptides contain a free amine group end and a free carboxyl group end. N-terminus and C-terminus are the two termini of a peptide. The main difference between N-terminus and C-terminus is that N-terminus is the end of the peptide with a free amine group (-NH2), whereas C-terminus is the end of the peptide with a free carboxyl group (-COOH). ![]() ![]() ![]() ![]() 16U/U17 and above National champion in styleģ. U17 and above World placer in and out of styleĢ. Separation Criteria for 16U Men's Freestyleġ. This also means that highly ranked wrestlers with low criteria or no criteria could serve as hand grenades haphazardly thrown into a bracket to blow it up. ![]() As a rule of thumb, the wrestlers you see with high criteria are unlikely to meet until later in the tournament. Wrestlers meeting criterion #1 will be spread out from other #1s, etc. For the uninitiated, Fargo isn’t seeded, but the best wrestlers are separated based on the ten criteria below. We're running a new-subscriber special.Before diving into these weights, get caught up on the separation criteria that will be dictating the brackets. "Please continue to love," said Webber, who was disassociated from Michigan for 10 years because of the Ed Martin scandal. Webber was the last honoree to arrive for Saturday night's ceremony - in attendance were such dignitaries as Pistons general manager Troy Weaver, Pistons coach Dwane Casey, retired Michigan softball coach Carol Hutchins, retired Michigan football broadcaster Jim Brandstatter and boxing legend Thomas "Hitman" Hearns - and he was more than worth the wait. Both Billups and Gates sent pre-recorded messages accepting their honors. Chargers front office, also couldn't attend. ![]() They couldn't make last year's ceremony, and Billups, now head coach of the Portland Trail Blazers, couldn't attend Saturday, either. Others in the class included Battier, Red Wings broadcaster Mickey Redmond, NFL legend Antonio Gates, former Pistons great Chauncey Billups and former Western Michigan athletic director Kathy Beauregard.īillups and Battier were being inducted as part of the Class of 2020. Webber headlined a very Wolverine-heavy Michigan Sports Hall of Fame class, which included former basketball coach John Beilein, softball legend Jennie Ritter and ice dancers Charlie White and Meryl Davis. "So many of these guys that I admire," Webber continued, "I'm glad that when all is said and done, those that I admire, I'm with them in a conversation about Michigan, and it's pretty cool." "I went to school through you," Webber said of George Blaha, the long-time voice of the Pistons and Michigan State football, and now a fellow MSHOF member. He played briefly for the Pistons in 2007, retired in 2008 and became a broadcaster. Webber played for five NBA teams, most notably Washington and Sacramento. 1 overall pick in the 1993 NBA Draft, by the Orlando Magic. Webber left Michigan after two seasons and was the No. (Dad, bringing levity to the situation, apparently had a license plate that read: TIMEOUT). Webber touched on that in his speech, too, and credited father Mayce with helping him get through all the fallout - and there was a whole lot of it - from that moment. Michigan lost both, the second marred by the infamous timeout that Webber called - and that Michigan didn't have. He was Big Ten freshman of the year in 1992 and a consensus All-American in 1993, leading the Wolverines to back-to-back championship games. He headlined a star-studded recruiting class at Michigan, which came to be known as the "Fab Five." Webber went on to star at Detroit Country Day, and was Mr. He told of the sob stories coaches would tell him if he didn't sign with them. Even then, college coaches were after him hard. Webber told stories about the pressures he faced growing up in Detroit, as a 12-year-basketball prodigy. View Gallery: Michigan Sports Hall of Fame 2022 inductees ![]() ![]() ![]() Our Linux server monitoring software provides a single pane of glass from which administrators can track key Linux monitoring server metrics such as CPU usage, memory usage, disk I/O utilization, system load, network traffic, process details, thread count, process count, zombie process count, etc. With SSH and SNMP modes for Linux monitoring, collect and monitor Linux server performance statistics such as overall resource usage, resource usage by workload, and resolve issues by drilling into performance metrics. Linux server health monitoring will help you guarantee maximum health and availability of your Linux server monitor. Leverage Applications Manager's Linux server monitoring capabilities to monitor the critical metrics of your Linux servers. Optimal Linux server monitoring tools play a vital role in ensuring the performance and availability of your applications. With Applications Manager's Linux performance monitoring capabilities you can : Track health and availability stats for all round Linux monitoring. Ensure key performance metrics of your Linux monitor like CPU, memory, disk utilization, etc are within permissible limits by getting instant notification when thresholds are violated. Datadog can monitor both application and server performance on cloud servers, so it is well suited to the task of overseeing the performance of AWS. ![]() It can be installed on either Linux or Windows OS. Datadog AWS Monitoring (FREE TRIAL) Amazon Web Services offers a menu of applications as well as virtual servers to run them on. As a result, the need for Linux monitoring tools becomes inevitable for IT teams that have to monitor Linux servers.Īpplications Manager's Linux monitoring tool empowers administrators by providing extensive support for various Linux distributions. Cacti is one of the best-known names in open-source network monitoring software. It comes with a web based user interface where you can. Needless to say, Linux server performance monitoring is one of the core responsibilities of the IT team in order to detect performance issues that could impact business service continuity. PHP Server Monitor is a script that checks whether your websites and servers are up and running. As the number of distributions in the organizations increase, Linux performance monitoring becomes complicated. It’s one of the most widely used commands by Linux system. With its highly reliable and scalable design, Linux is one of the most popular operating systems for business across the globe. 1.Without any doubt, the top command is the number one command-line tool to monitor Linux. ![]() ![]() ![]() It may seem quite complex to begin with, but we’ll take you through the basics to get you up and running as quickly as possible. Once you have downloaded and installed OBS Broadcaster, you will see a screen that looks somewhat like what is shown below. OBS is mostly used as a video game streaming tool, but you can also use it to record your own screen and save the videos to your local drive. Windows Game Bar can be a great way to quickly record your screen, but if you want more control, we’d suggest using OBS Broadcaster. Free Screen Recording Software – OBS Broadcaster If you need to do that or need to record the entire screen regardless of which app is active, then you should check out our second suggestion below. The one big downside to Game Bar is that you can’t use it to record your desktop or Windows Explorer. Windows Game Bar was specifically created to record your video game moments, but you’ll find that it works perfectly well for recording your screen in any other standard program as well.įor some programs like a web browser or something like Adobe Photoshop, etc., you’ll get a message stating gaming features are not available for this app and you have to check a box to enable it. Alternatively, you can choose to record no sound whatsoever, or record all audio on your computer. Next, scroll through the settings menu that pops up, and select Game Only under the Audio to record section. You can turn the microphone back off again by pressing the same keys again.įinally, if you’d like to record the audio from the application you are currently using, but don’t want to record audio from any apps in the background, press Windows Key + G to open the Game Bar, then click the Settings cog on the left hand side. If you’d like to turn on your microphone and record your voice whilst you are recording a video, you can use the shortcut Windows Key + Alt + M. By default, your recordings will be named after whichever program you have open and in view at the time. You’ll find all of your new saved recordings there. To access your new recording, go to This PC, Videos, then Captures. You will now see a small recording icon in the top right hand of your screen.Īt any point you can click the Stop button to stop recording, or you can press Windows Key + Alt + R again to stop it. Alternatively, you can press Windows Key + Alt + R. To start recording, click the Start Recording button (the circle with the black dot). ![]() If it still doesn’t load, click on Start – Settings – Gaming – Game Bar and make sure it’s turned On. If nothing happens, that means you need to go to the Windows Store and download the Game Bar app. In the latest version of Windows, Windows 10 1809, the game bar has been redesigned a looks like this: Below, we have provided a screenshot for reference. Doing this will open the Windows 10 Game Bar. ![]() |
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